In a stunning breakthrough, researchers have identified 10 specific blood “markers” that separate centenarians from those who die earlier, allowing them to predict who’s more likely to reach 100 years.
Once considered medical marvels, centenarians are no longer as rare as they once were. In fact, the venerable population – people 100+ years – now represents the fastest-growing age group globally, with their numbers roughly doubling every decade since the 1970s.
And a groundbreaking long-term study from Sweden may have the answers.
Tracked longevity for decades
Researchers analyzed 44,637 people from Stockholm County using data from a massive population-based resource of clinical lab results. These participants, all born between 1893 and 1920 (ages 64 to 99), had routine blood tests performed between 1985 and 1996. Then came the long wait: participants were tracked for up to 35 years, using national registers that recorded disease, death, and residency status.
Of these people, 1,224 reached the age of 100, with 84.6% being women – consistent with known gender differences in longevity.
But the researchers weren’t just interested in outcomes. They wanted to know if blood markers, taken decades earlier, reveal who would eventually live the longest.
Turns out, yes – at least to some degree.
Extreme values
The scientists looked at 12 routine blood markers. These included:
- Glucose and total cholesterol for metabolic health
- Creatinine for kidney function
- Liver enzymes such as gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), and lactate dehydrogenase (LD)
- Iron markers and uric acid, often associated with inflammation
- Albumin, which signals nutritional status
Key findings
“We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their 60s onwards,” researcher Karin Modig writes in a Live Science article. “For example, very few of the centenarians had a glucose level above 6.5 earlier in life, or a creatinine level above 125.”Continue reading…