But does gabapentin cause dementia?
Not necessarily. The researchers were careful to note this was an observational study, meaning it shows a strong association — not proof of direct cause.
Still, the dataset was huge, and the findings aligned with other emerging concerns about gabapentin’s side effects.
Why gabapentin use has skyrocketed
Gabapentin has been around since the early ’90s, originally approved to treat epilepsy. Over the years, doctors have increasingly turned to it for chronic pain, nerve pain, post-shingles pain, and restless legs syndrome because it’s seen as a safer alternative to opioids.
It’s often prescribed long-term for back pain, even though researchers note that many patients receiving it may also struggle with mobility — another known dementia risk factor.
But in this study, gabapentin users were matched with similarly limited patients who didn’t take the drug, suggesting mobility alone doesn’t explain the cognitive decline.
